Top 5 Venture Capital Firms in Louisville, Kentucky [2022]

With $200 million invested across 51 deals in 2021, Louisville has a number of leading venture capital firms for startups that wish to set ground in Kentucky.

Whether you are raising seed, Series A or higher, in this article we have listed our top picks for the best venture capital firms in Louisville, Kentucky, with each their industry focus and typical investment size.

So, if you haven’t yet started to reach out, here is a good place to start learning about them.

This article is part of a series where we present you the top Venture Capital firms across the US. For the Mid West, check out our rankings for Chicago, Indianapolis, Columbus, Detroit, Charlotte, Minneapolis and Milwaukee.
Looking for Louisville's top startup incubators and accelerators instead? Check out our ranking here.

Top 5 Venture Capital Firms in Louisville, Kentucky

Here’s a summary of our top 5 picks for the best venture capital firms in Louisville, Kentucky (in alphabetical order):

NameSector focusRoundInvestment sizeInvestments
Chrysalis VenturesHealthcare and TechnologySeries AN/A55
Keyhorse CapitalTechnology-enabledSeed, Series AN/A79
Poplar VenturesTechnology-enabledSeries AN/A12
Radicle CapitalTechnology-enabled and Social & Environment focusedSeed, Series AN/A19
Scalable VenturesMarketplaces, Platforms, Analytics, Web3, AI & ML, SaaS, eCommerce, Mobile AppsSeed, Series AN/A14

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1. Chrysalis Ventures

Louisville’s one of the top venture capital firms, Chrysalis Ventures known for offering Series A funding to technology and healthcare companies. The firm does not just offer to fund, but also offers active collaboration to help the portfolio companies achieve sustainable success.

Unfortunately, Chrysalis Ventures doesn’t disclose the exact investment amount anywhere on its website. However, they only select those companies for investment that show promise of high growth. Also, the companies applying for funding must be operating in the Midwest and Southeast.

So far, this venture capital firm has invested in 55 companies, some of which include big names like AT&T, TechRepublic, Rad Technologies, WebMD, Intechra, and Foundation Radiology Group, among others.

2. Keyhorse Capital

Keyhorse Capital is yet another popular venture capital firm operating in Louisville. However, the firm also has a physical presence in Lexington. This venture capital firm offers Seed and Series A funding to companies working in technology-enabled sectors.

Interestingly, Keyhorse Capital invests only in those companies that are either located in Kentucky or are willing to relocate to Kentucky. Also, the companies applying for funding must have a prototype or an MVP.

Unfortunately, Keyhorse Capital does not disclose the exact investment amount anywhere on its website. So far, this venture capital firm has invested in 79 companies, some of which are Cloverleaf, C2 Keep, BrainSTEM, FlyWire, Gun Media, Onovative, Revon Systems, SentryHealth, and Victory Hemp Foods, among others.

3. Poplar Ventures

Louisville’s another popular venture capital firm is Poplar Ventures. This venture capital firm offers Series A investment to tech-enabled companies. Their primary focus is on companies in the B2B software segment with the ability to disrupt the existing markets.

Unfortunately, Poplar Ventures does not disclose the exact investment amount anywhere on their website. So far, this venture capital firm has invested in 12 companies, and it has a track record of working closely with its portfolio companies.

Some of the various companies that Poplar Ventures has invested in include DVINCI, Vivid Charts, SKUVault, BehaVR, and QASymphony, among others.

4. Radicle Capital

Radicle Capital is another famous venture capital firm operating in Louisville. This venture capital firm offers both Seed and Series A investments to companies that are technology-enabled and those focusing on society and the environment. Unfortunately, the venture capital firm chooses to keep its exact investment amount undisclosed.

Apart from offering funds, Radicle Capital takes up board representation and helps its portfolio companies with scaling, fundraising, strategy and business development, and other aspects of their businesses.

So far, Radicle Capital has invested in 19 companies, some of which are Advanced Cancer Therapeutics, Ocean Organic Vodka, Stony Creek Colors, Sproutel, and Patamar Capital, among others.

5. Scalable Ventures

Louisville-based Scalable Ventures offers Seed and Series A funding to scalable software companies working in the B2B segment. In particular, this venture capital firm is interested in companies working in Analytics, Platforms, Marketplaces, AI/ML, Web3, SaaS Mobile and Web Apps, and E-Commerce segments.

Just like every other venture capital firm on this list, Scalable Venture doesn’t disclose the exact investment amount anywhere on its website.

So far, this venture capital firm has invested in 14 companies with some of them being Dianthus, MicroAcquire, ImageProVision, Capture, SentryHealth, SuperFan, and Talla. Interestingly, several of its portfolio companies have been acquired by other companies.

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