The 3 Best Pharmacy Franchises of 2025 in the USA

The pharmacy industry plays a vital role in the U.S. healthcare system, with growing demand for prescription medications, over-the-counter products, and health services. The U.S. pharmaceutical market is projected to reach $605 billion by 2027, driven by an aging population and the increasing prevalence of chronic diseases.

For entrepreneurs, investing in a pharmacy franchise offers a stable and profitable business opportunity with an established customer base.

In this guide, we’ll explore the best pharmacy franchises, detailing key factors such as startup costs, franchise fees, and revenue potential to help you make an informed investment decision.

The 3 Best Pharmacy Franchises of 2025

The most profitable franchises to own in 2025

We have compiled the list of the top 400 franchises across 9 industries. Download the report below.

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Good Neighbor Pharmacy

Franchising Since: 2009
Franchised Units: 2,502
Initial Investment: $279,000 - $575,000
Franchise Fee: N/A
Royalty Fee: N/A

Good Neighbor Pharmacy is a chain of locally owned independent pharmacies tied together by their relentless desire to provide personalized patient care throughout the US.

Headquartered in Conshohocken, Pennsylvania, Good Neighbor Pharmacy has become a healthcare destination for anyone seeking tailor-made care from pharmacists who prioritize overall health and wellness. Founded in 1982, Good Neighbor Pharmacy provides a network of franchises that sell medicines while positively impacting communities.

As a subsidiary of AmerisourceBergen Corporation, a giant drug wholesale and Distribution Company, Good Neighbor Pharmacy has expanded to numerous locations in recent years, operating over 2500 pharmacies in the US as of 2023.

Health Mart Pharmacy

Franchising Since: 1997
Franchised Units: 4,657
Initial Investment: $251,000 - $674,000
Franchise Fee: N/A
Royalty Fee: $390 per month

Health Mart Pharmacy is an independent chain of pharmacies dedicated to improving the health and well-being of their clients. Founded in 1997, Health Mart Pharmacy takes its time to deliver a tailored experience to not only keep their patients healthy but also set a matchless legacy within their communities.

Headquartered in San Francisco, California, Health Mart also provides a streamlined online shopping experience, giving everyone access to a range of health and wellness products and medicines from the comfort of their homes. As a trusted name in the highly rewarding pharmaceutical industry, Health Mart offers a lucrative franchise opportunity, making it easier for anyone to manage their health and well-being without worrying about sudden inconveniences, unnecessary delays, or unexpected drug shortages.

Health Mart offers fast prescription, home delivery, monthly prescription pickup, prescription reminders and refills, prior authorizations, prescription savings, and quality Health Mart products. Many Health Mart pharmacies also offer vaccines, medication consultations, diabetes management, and health classes as part of their comprehensive services. With over 5000 member pharmacies across 50 US states, the future looks bright for the California-based chain of pharmacies that continues to expand by tapping into new opportunities.

Medicap Pharmacy

Franchising Since: 1974
Franchised Units: 67
Initial Investment: $130,000 - $961,000
Franchise Fee: $0
Royalty Fee: 3.00%

Medicap Pharmacy is a franchisor of pharmacy stores built upon the principles of client satisfaction, professional care, and attention to detail. Founded in 1971, Medicap Pharmacy believes that no two clients share the same requirements as far as healthcare goes. Thus, they use a professional, customized approach when it comes to caring for their clients and their families.

Headquartered in Mooresville, North Carolina, Medicap Pharmacy provides a profitable, result-driven franchise opportunity, specializing in flu and strep testing, immunizations, medication synchronization, medication therapy management, and multi-dose packaging.

Apart from supporting franchisees looking to set up new pharmacies or acquire existing facilities, Medicap Pharmacy also works closely with independent pharmacy owners to help increase their revenue potential by leveraging the power of an established brand. Franchising since 1971, Medicap Pharmacy is steadily setting the pace as one of America’s most trusted healthcare advisors, operating in over 60 locations across the country. 

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