The 9 Best Medical Spa Franchises of 2025 in the USA
The medical spa industry is experiencing rapid growth as demand for non-invasive cosmetic treatments continues to rise. With the global medical spa market projected to reach $25.9 billion by 2026, this sector offers a lucrative opportunity for entrepreneurs looking to invest in a wellness-focused business.
Medical spa franchises provide a proven business model and a way to tap into this thriving market.
In this guide, we’ll explore the best medical spa franchises of 2025, covering essential details like startup costs, franchise fees, and growth potential to help you make an informed investment decision.
The Best Medical Spa Franchises of 2025
| Franchise | Offering Franchises Since | Locations* | Investment Range | Revenue |
|---|---|---|---|---|
| Live Hydration Spa | 2021 | 10 | $147,000 – $320,000 | $406,000 |
| QC Kinetix | 2020 | 159 | $227,000 – $496,000 | $467,000 |
| The DripBar | 2019 | 40 | $142,000 – $405,000 | $93,000 |
| 4Ever Young | 2019 | 16 | $355,000 – $725,000 | $958,000 |
| CHILLRx Cryotherapy | Not available | 3 | $260,000 – $312,000 | $212,000 |
| Liquivida Lounge | Not available | 7 | $108,000 – $930,000 | $1,449,000 |
| OrthoLazer | Not available | 14 | $414,000 – $522,000 | $369,000 |
| Prime IV Hydration & Wellness | 2020 | 47 | $76,000 – $600,000 | $550,000 |
| The Salt Suite | 2015 | 8 | $239,000 – $483,000 | $240,000 |
The most profitable franchises to own in 2025
We have compiled the list of the top 400 franchises across 9 industries. Download the report below.
Live Hydration Spa
Franchising Since: 2021
Franchised Units: 10
Initial Investment: $147,000 to $320,000
Franchise Fee: $49,500
Royalty Fee: 7.50%
Live Hydration Spa is an IV therapy spa franchise headquartered in Omaha, Nebraska. It offers IV hydration in addition to vitamins, minerals, and amino acids. Its individually tailored IV nutrition programs help boost energy, improve the immune system, improve circulation and hydration, decrease inflammation, and improve the mental focus and concentration of their clients.
Live Hydration Spa was founded in 2018 and began franchising in 2021, and by the end of 2022, it had opened 10 franchises in the US. Over the years, the company has positioned itself competitively through improved service delivery, a focus on wellness versus one-and-done treatments to enhance client retention, and an improved business system.
With IV Vitamin infusion therapy being one of the fastest-growing health services in the US, the Live Hydration Spa franchise offers a promising career to potential franchise owners to build a strong career that has potential and is scalable to multiple units.
QC Kinetix
Franchising Since: 2020
Franchised Units: 159
Initial Investment: $227,000 to $496,000
Franchise Fee: $55,000
Royalty Fee: 8.00%
QC Kinetix is a nonsurgical medical franchise headquartered in Charlotte, North Carolina that offers customized regenerative medicine treatments. Its centers provide comprehensive regenerative medicine, including biological therapies, laser therapy, nutritional support, and restorative treatments.
QC Kinetix was founded in 2017 and began franchising in 2020, and by 2022, it had 128 franchises in the US and 10 company-owned locations.
The founder’s goal was to empower patients against their pain, and their idea led to the founding of a leading regenerative medical provider. QC Kinetix has grown through franchises in multiple locations across the country.
The global regenerative medicine market is expected to reach 48.9 billion dollars by 2025, and QC Kinetix is strategically positioned to offer passionate investors a great investment opportunity in this emerging and rewarding field, with multi-unit opportunities available that allow franchises with limited medical expertise to deliver results in their local communities.
The DripBar
Franchising Since: 2019
Franchised Units: 40
Initial Investment: $142,000 to $405,000
Franchise Fee: $55,000
Royalty Fee: 7.00%
The DripBar is an IV drip therapy franchise based in Wrentham, Massachusetts.
It offers a variety of healthcare services focused on advances in intravenous therapies such as IV lifestyle drips, drip parties, IV health support drips, IM shots, etc.
The DripBar was founded in 2016 with the mission to help its clients achieve optimal health and feel their best by focusing on cellular health. It began franchising in 2019, and by the end of 2022, it had opened 28 franchises in the US.
Driven by its unique combination of modern scientific knowledge, medical expertise, and caring drip experts, The DripBar is emerging as a leading franchise in a fast-growing industry with a great business model, flexible schedules, and scalable business ideas in prime locations.
The DripBar IV drip therapy franchise is a potential opportunity with multiple income streams for passionate franchisees who want to help people live their best, healthy lives.
4Ever Young
Franchising Since: 2019
Franchised Units: 16
Initial Investment: $355,000 to $725,000
Franchise Fee: $60,000
Royalty Fee: 7.00%
4Ever Young is an anti-aging clinic and medical spa committed to helping individuals slow down the aging process using industry-proven anti-aging solutions and personalized treatment plans. It was founded in 2014 by Deniz Duygulu and Carlton Washington and has quickly established itself among the most reputable names in the multi-billion dollar anti-aging industry.
With the anti-aging market expected to reach about $93 billion by 2027, 4Ever Young offers the perfect franchise opportunity for anyone keen to capitalize on this growth while helping people improve their looks.
After opening its first location in Florida, 4Ever Young increased its scope and popularity thanks to its proactive approach to healthy aging, andropause, menopause, IV nutrition, weight loss, and detoxification, among other services. Franchising since 2019, 4Ever Young Anti Aging had opened 12 franchised units across the US as of 2022.
CHILLRx Cryotherapy
Franchising Since: 2017
Franchised Units: 3
Initial Investment: $260,000 to $312,000
Franchise Fee: $30,000
Royalty Fee: 6.00%
CHILLRx Cryotherapy is an emerging cryotherapy brand that aims to become a premier name in the fast-growing health and wellness industry. Founded in 2015 in Westfield, New Jersey, by Julie Shanebrook, CHILLRx Cryotherapy provides a lucrative business model using a safe, drug-free, and non-invasive treatment method to make clients feel better and live healthier lives.
Backed by a team of highly trained cryotechnicians, CHILLRx Cryotherapy is the roadmap to a peaceful and satisfying life, offering a range of cryotherapy services for beauty and anti-aging, weight loss, wellness management, injury, performance, and recovery, optimal health, and pain relief.
CHILLRx Cryotherapy specializes in whole-body cryotherapy, infrared sauna and light therapy, slim pod, NormaTech compression, celluma LED light therapy, and vitamin injections, among other services to improve blood circulation, help burn calories, reduce pain, aid muscle recovery, and boost the immune system.
Franchising since 2015, CHILLRx Cryotherapy brings the chill experience home with its highly qualified team, allowing franchisees to leverage the increasing demand for cryotherapy.
The most profitable franchises to own in 2025
We have compiled the list of the top 400 franchises across 9 industries. Download the report below.
Liquivida Lounge
Franchising Since: 2021
Franchised Units: 7
Initial Investment: $108,000 to $930,000
Franchise Fee: $40,000
Royalty Fee: 6.00%
Liquivida Lounge is an IV therapy clinic and a full-service medical spa headquartered in Fort Lauderdale, Florida. Founded in 2014 by renowned paramedic and firefighter Samael Tejada, Liquivida Lounge is the epitome of comfort and relaxation, providing a spa-esque experience to anyone seeking alternative medicine solutions for a healthy and more fulfilling life.
After starting as a vitamin IV therapy storefront in Fort Lauderdale, Samael and his business partner, Dr. Samuel Hess, quickly realized that many people were battling stress and poor nutrition on a daily basis. Some simply needed energy and renewed vitality. However, all of them didn’t have the right tools to help accelerate the progress toward achieving any of these goals. So, Liquivida Lounge created a comprehensive solution to meet these needs, covering different aspects of health and wellness, including weight loss, telehealth, hormone replacement, sexual wellness, and beauty and skincare.
Today, Liquivida Lounge has grown into a full-service medical spa that’s all about replenishing, revitalizing, and rehydrating the general population through perfectly crafted weight loss solutions, medical aesthetics, and vitamin IV therapy. With a multi-million dollar business model, 4000 affiliated doctors, 5 integrated lounges, and 21 wellness centers across the US, it’s no surprise that the medical spa gets ranked as the #1 vitamin therapy provider in the US.
OrthoLazer
Franchising Since: Not available
Franchised Units: 14
Initial Investment: $414,000 to $522,000
Franchise Fee: $49,500
Royalty Fee: 8.00%
OrthoLazer is a pain control clinic that has continued to transform people’s lives using safe, drug-free, and non-invasive treatment solutions since it was launched by Dr. Scott Sigman and Joann Pennington in 2018.
Headquartered in Rochester, New York City, OrthoLazer started as a highly innovative clinic with a mission to provide a happy, fulfilling, and pain-free life using advanced laser therapy. Its unprecedented growth paved the way for the highly successful franchise model, further increasing its popularity throughout the US and beyond.
Today, OrthoLazer is a lucrative opportunity for orthopedic surgeons keen to maximize their income while using the highly advanced MLS M8 Robotic Laser to help clients manage pain and inflammation resulting from acute and chronic orthopedic conditions.
Prime IV Hydration & Wellness
Franchising Since: 2020
Franchised Units: 47
Initial Investment: $76,000 to $600,000
Franchise Fee: $49,000
Royalty Fee: 7.00%
Prime IV Hydration & Wellness is a premier IV hydration therapy clinic based in Arizona. It was founded in 2017 by Amy Mullins Neary and has been at the forefront of IV vitamin therapies, formulating effective solutions to optimize clients’ health and well-being.
The medical franchise uses state-of-the-art equipment to offer 10 specialized infusions with 100% guaranteed vitamin absorption. As a premier IV hydration therapy clinic, it helps alleviate the symptoms of countless ailments and conditions, including migraines, dehydration, fatigue, anti-aging, seasonal allergies, hangover recovery, and sun exposure.
Since beginning its franchise operations in 2020, the chain has expanded its services to 47 locations, all of which are franchised in the US. As a franchisee, you will become part of an up-and-coming IV hydration therapy industry that’s expected to grow by 7.97% between 2023 and 2030.
The Salt Suite
Franchising Since: 2015
Franchised Units: 8
Initial Investment: $239,000 to $483,000
Franchise Fee: $42,000
Royalty Fee: 8.00%
The Salt Suite is a salt therapy franchise that has excelled with its innovative approach to health and wellness. Founded in 2011 by Jessica and Elliott Helmer, The Salt Suite is a place for relaxation, healing, and wellness through membership-based redlight and salt therapies.
The Salt Suite helps clients immerse themselves into the world of salt therapy and enjoy the countless benefits of the natural remedy, such as improved lung function, clearing toxins and pollens from the nasal tracts and lungs, providing skin relief from eczema, dermatitis, and other skin conditions, and reducing the symptoms of asthma and allergies.
With more and more Americans switching from big pharma to conservative treatment methods, the Salt Suite provides an exciting opportunity to anyone seeking natural ways to recharge and revitalize to improve their quality of life.
Franchising since 2015, The Salt Suite continues to set the pace in the salt therapy industry, with over 9 franchised locations in the US as of 2023.
